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Arrhythmias in the developing heart
Author(s) -
Sedmera D.,
Kockova R.,
Vostarek F.,
Raddatz E.
Publication year - 2015
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.12418
Subject(s) - medicine , heart rhythm , heart block , long qt syndrome , cardiology , pathogenesis , rhythm , electrocardiography , intensive care medicine , pediatrics , qt interval
Prevalence of cardiac arrhythmias increases gradually with age; however, specific rhythm disturbances can appear even prior to birth and markedly affect foetal development. Relatively little is known about these disorders, chiefly because of their relative rarity and difficulty in diagnosis. In this review, we cover the most common forms found in human pathology, specifically congenital heart block, pre‐excitation, extrasystoles and long QT syndrome. In addition, we cover pertinent literature data from prenatal animal models, providing a glimpse into pathogenesis of arrhythmias and possible strategies for treatment.