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Compartmentation of c AMP signalling in cardiomyocytes in health and disease
Author(s) -
Perera R. K.,
Nikolaev V. O.
Publication year - 2013
Publication title -
acta physiologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.591
H-Index - 116
eISSN - 1748-1716
pISSN - 1748-1708
DOI - 10.1111/apha.12077
Subject(s) - phosphodiesterase , microbiology and biotechnology , second messenger system , signalling , adenosine , receptor , function (biology) , signal transduction , biology , adenosine monophosphate , cardiac hypertrophy , kinase , neuroscience , muscle hypertrophy , chemistry , biochemistry , endocrinology , enzyme
3′,5′‐cyclic adenosine monophosphate (c AMP ) is a ubiquitous second messenger critically involved in the regulation of heart function. It has been shown to act in discrete subcellular signalling compartments formed by differentially localized receptors, phosphodiesterases and protein kinases. Cardiac diseases such as hypertrophy or heart failure are associated with structural and functional remodelling of these microdomains which leads to changes in c AMP compartmentation. In this review, we will discuss recent key findings which provided new insights into c AMP compartmentation in cardiomyocytes with a particular focus on its alterations in heart disease.