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Clinical Spectrum of the Syndrome of Growth Hormone Insensitivity
Author(s) -
SAVAGE M.O.,
CHATELAIN P.G.,
PREECE M.A.,
RANKE M.B.,
SIETNIEKS A.,
WILTON P.
Publication year - 1991
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.1991.80.s377.87
Subject(s) - medicine , growth hormone , spectrum (functional analysis) , pediatrics , hormone , endocrinology , physics , quantum mechanics
A survey of 46 patients with suspected growth hormone (GH) insensitivity is presented. Clinical details and plasma samples from these patients were analysed centrally. A diagnostic score based on basal levels of GH and insulin‐like growth factor I (IGF‐I), IGF‐I response to GH (0.1 U/kg daily for 4 days) and height SDS was determined for all patients to identify those with GH insensitivity. A total of 29 such patients was identified (14 males and 15 females; age range, 3.2–22.6 years). Their mean height SDS was −6.0 (range, −8.9 to −2.6), mean weight SDS was −2.9 (range, −5.2 to 1.2). Pubertal development was delajed in three out of three boys and two out of six girls of pubertal age. Their basal GH level was 32.4 mU/l (range, 0.8–158.2 mU/l) and mean basal IGF‐I level was 33.6 ng/ml (range, 20–97 ng/ml). None of the 29 patients showed a significant serum IGF‐I response to injections of GH.