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Relation between Essential Fatty Acid Metabolism and Gastrointestinal Symptoms in Cystic Fibrosis
Author(s) -
STRANDVIK B.
Publication year - 1989
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.1989.78.s363.58
Subject(s) - cystic fibrosis , medicine , arachidonic acid , disease , metabolism , natural history , fatty acid , lipid metabolism , fibrosis , endocrinology , gastroenterology , biochemistry , biology , enzyme
Studies in our laboratory have supported the hypothesis, that the basic defect in cystic fibrosis increases the metabolism of essential fatty acids and thereby gradually gives rise to essential fatty acid deficiency, which is a well documented finding in most cases with this disease. Both the increased metabolism—giving high liberation of arachidonic acid and its metabolic products, i.e. different eicosanoids—and the subsequent essential fatty acid deficiency will cause gastrointestinal symptoms and the sequence of this development will mirror the natural history of the disease. Clinical data and results from animal research are discussed in relation to gastrointestinal symptoms and signs of cystic fibrosis.