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CYSTIC FIBROSIS‐LIKE CHANGES IN BODY FLUIDS OF HEALTHY PERSONS PERFORMING ANAEROBIC EXERCISE
Author(s) -
CEDER OVE,
TEIEN DAG,
BARDOŃ ALICJA,
HELLSING KRISTOFFER,
KOLLBERG HANS
Publication year - 1983
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.1983.72.s309.25
Subject(s) - cystic fibrosis , saliva , anaerobic exercise , medicine , heterozygote advantage , endocrinology , urine , excretion , physiology , genotype , biochemistry , chemistry , gene
Ceder, O., Teien, D., Bardoń, A., Hellsing, K. and Kollberg, H. (Department of Pediatrics, University Hospital, Umeå, Sweden, Department of Clinical Physiology, University Hospital, Umeå, Sweden, Department of Clinical Chemistry, University Hospital, Uppsala, Sweden, Department of Biochemistry, Institute of Sport, Warsaw, Poland and Department of Pediatrics, University of Kuwait, Safat, Kuwait). Cystic fibrosis‐like changes in body fluids of healthy persons performing anaerobic exercise. Acta Paediatr Scand 1983, Suppl. 309: 25. The biochemical compositions of blood, saliva and urine were compared at rest and during and after anaerobic physical exercise in homozygotes and heterozygotes for cystic fibrosis (CF) and in healthy controls. At rest there were only minor differences in blood compositions between the three genotypes. In saliva significantly higher resting values were found for ribonuclease, protein and sodium in homozygotes than in healthy controls. Heterozygotes showed saliva ribonuclease and protein values similar to those of CF patients. At rest both homozygotes and heterozygotes had higher urinary excretion of pyruvate, lactate, ribonuclease, sodium, chloride and potassium than healthy controls. Anaerobic effort caused increases in the blood values of citrate, pyruvate and ribonuclease which were similar in the three genotypes. Lactate rose to a lesser extent in homozygotes, however, than in the other two groups. In saliva anaerobic exercise caused increases in pyruvate, lactate, protein, ribonuclease and electrolytes in both controls and heterozygotes giving values similar to those of the homozygotes. After anerobic exercise the urinary excretions of pyruvate, lactate and ribonuclease increased and the excretions of citrate and electrolytes decreased in controls and heterozygotes.