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The chance of spontaneous patent ductus arteriosus closure in preterm infants born before 32 weeks of gestation is high and continues to increase until 5 years of follow‐up
Author(s) -
Nielsen Mette Rønn,
Aldenryd Anna Elisabet,
Hagstrøm Søren,
Pedersen Lia Mendes,
Brix Ninna
Publication year - 2022
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.16541
Subject(s) - ductus arteriosus , medicine , gestation , pediatrics , retrospective cohort study , gestational age , cohort , obstetrics , surgery , pregnancy , genetics , biology
Aim The primary aim was to estimate premature infants' spontaneous patent ductus arteriosus closure rate. Secondly, to identify criteria associated with the chance of spontaneous closure. Methods We performed a retrospective cohort study of 167 infants born before 32 weeks of gestation and diagnosed with a patent ductus arteriosus between 1 January 2008 and 31 December 2017. The spontaneous patent ductus arteriosus closure event rate was evaluated using the Kaplan–Meier estimator. Results The spontaneous closure rate within the first year of life was 66% (95% CI 58%–73%), increasing to 80% (95% CI 72%–86%) five years after birth. When including both spontaneous closure and closure following treatment, 96% (95% CI 86%–100%) closed within 5 years after birth. The chance of spontaneous closure was reduced in the case of a large patent ductus arteriosus: OR 0.16 (95% CI 0.05–0.52), left atrial enlargement: OR 0.16 (95% CI 0.05–0.51), and pulmonary hypertension: OR 0.23 (95% CI 0.07–0.74). Conclusion The chance of spontaneous closure in premature infants born between 23 and 32 weeks of gestation was high, and the incidence continued increasing until 5 years of follow‐up.