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Amino acid infusions in umbilical artery catheters enhance protein administration in infants born at extremely low gestational age
Author(s) -
Gialamas Spyros,
Stoltz Sjöström Elisabeth,
Diderholm Barbro,
Domellöf Magnus,
Ahlsson Fredrik
Publication year - 2022
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.16196
Subject(s) - medicine , umbilical artery , gestational age , incidence (geometry) , catheter , pregnancy , gestation , pediatrics , anesthesia , obstetrics , surgery , genetics , physics , optics , biology
Aim It is challenging to provide extremely low gestational age neonates (ELGANs) with adequate protein supply. This study aimed to investigate whether amino acid (AA) infusion in the umbilical artery catheter (UAC) in ELGANs is safe and enhances protein supply and growth. Method A before and after study including infants born <27 weeks, treated in Uppsala, Sweden, during 2004–2007, compared those receiving normal saline/10% dextrose in water with those receiving AA infusion in the UAC. Data were retrieved from the Extremely Preterm Infants in Sweden Study, hospital records and the Swedish Neonatal Quality Register. Group comparisons, univariate and multivariate analyses were conducted. Results AA group ( n = 41, females 39%) received on average approximately 0.3 g/kg/day more protein during the first postnatal week, compared to control group ( n = 30, females 40%) (unstandardised coefficient ( B ) 0.26, p .001) but no difference was noted during 8–28 postnatal days. The type of infusion was not associated with growth variables. The incidence of neonatal morbidities and UAC‐related thrombosis did not differ between the groups. Conclusion AA infusions in the UACs in ELGANs is safe and enhances protein supply during the first postnatal week. However, this practice is not associated with growth during the first 28 postnatal days.