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Population‐based study of multisystem inflammatory syndrome associated with COVID‐19 found that 36% of children had persistent symptoms
Author(s) -
Kahn Robin,
Berg Stefan,
Berntson Lillemor,
Berthold Elisabet,
Brodin Petter,
Bäckström Fredrik,
Compagno Michele,
Fasth Anders,
Lingman Framme Jenny,
Horne AnnaCarin,
Hätting Josefin,
Król Petra,
Kukka Antti J,
Mossberg Maria,
Månsson Bengt,
Nordenhäll Charlotta,
Idring Nordström Selma,
Khammari Nyström Fatine,
Palmblad Karin,
Rasti Reza,
Rudolph André,
Rydenman Karin,
Sundberg Erik,
SäveSöderbergh Eva,
Altman Maria
Publication year - 2022
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.16191
Subject(s) - medicine , pediatrics , population , covid-19 , disease , environmental health , infectious disease (medical specialty)
Aim Our aim was to describe the outcomes of multisystem inflammatory syndrome in children (MIS‐C) associated with COVID‐19. Methods This national, population‐based, longitudinal, multicentre study used Swedish data that were prospectively collected between 1 December 2020 and 31 May 2021. All patients met the World Health Organization criteria for MIS‐C. The outcomes 2 and 8 weeks after diagnosis are presented, and follow‐up protocols are suggested. Results We identified 152 cases, and 133 (87%) participated. When followed up 2 weeks after MIS‐C was diagnosed, 43% of the 119 patients had abnormal results, including complete blood cell counts, platelet counts, albumin levels, electrocardiograms and echocardiograms. After 8 weeks, 36% of 89 had an abnormal patient history, but clinical findings were uncommon. Echocardiogram results were abnormal in 5% of 67, and the most common complaint was fatigue. Older children and those who received intensive care were more likely to report symptoms and have abnormal cardiac results. Conclusion More than a third (36%) of the patients had persistent symptoms 8 weeks after MIS‐C, and 5% had abnormal echocardiograms. Older age and higher levels of initial care appeared to be risk factors. Structured follow‐up visits are important after MIS‐C.