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Mode of delivery was associated with transient changes in the metabolomic profile of neonates
Author(s) -
Vidarsdottir Harpa,
Halldorsson Thorhallur Ingi,
Geirsson Reynir Tomas,
Bjarnason Ragnar,
Franzson Leifur,
Valdimarsdottir Unnur Anna,
Thorkelsson Thordur
Publication year - 2021
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15822
Subject(s) - medicine , vaginal delivery , cord blood , caesarean section , umbilical cord , amino acid , metabolomics , obstetrics , newborn screening , physiology , pregnancy , pediatrics , bioinformatics , biochemistry , biology , immunology , genetics
Aims To estimate potential differences in neonatal metabolomic profiles at birth and at the time of newborn screening by delivery mode. Methods A prospective study at Women's Clinic at Landspitali—The National University Hospital of Iceland. Women having normal vaginal birth or elective caesarean section from November 2013 to April 2014 were offered participation. Blood samples from mothers before birth and umbilical cord at birth were collected and amino acids and acylcarnitines measured by tandem mass spectrometry. Results from the Newborn screening programme in Iceland were collected. Amino acids and acylcarnitines from different samples were compared by delivery mode. Results Eighty three normal vaginal births and 32 elective caesarean sections were included. Mean differences at birth were higher for numerous amino acids, and some acylcarnitines in neonates born vaginally compared to elective caesarean section. Maternal blood samples and newborn screening results showed small differences that lost significance after correction for multiple testing. Many amino acids and some acylcarnitines were numerically higher in cord blood compared to maternal. Many amino acids and most acylcarnitines were numerically higher in newborn screening results compared to cord blood. Conclusion We observed transient yet distinct differences in metabolomic profiles between neonates by delivery mode.