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Chorioamnionitis and neurodevelopmental outcome in very preterm infants from 2007 to 2017—a population‐based study
Author(s) -
Konzett Karin,
Riedl David,
Stark Carmen,
Simma Burkhard
Publication year - 2021
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15715
Subject(s) - medicine , chorioamnionitis , bayley scales of infant development , bronchopulmonary dysplasia , psychomotor learning , gestational age , pediatrics , population , obstetrics , pregnancy , genetics , cognition , environmental health , psychiatry , biology
Aim The study compares neurodevelopmental outcome at 24 months corrected age of very preterm infants exposed to chorioamnionitis and controls. Peripartal parameters which may influence outcome are also investigated. Methods In this observational population‐based study, very preterm infants born between 2007 and 2017 were eligible ( n = 466) and included if a histological placental examination and a complete neurodevelopmental assessment (Bayley Scale of Infant Development II or III) ( n = 168) were performed. Secondary analyses were calculated to identify peripartal factors that significantly influence mental and psychomotor outcome. Results Included infants showed a mean MDI of 91.2 ( SD = 20.7) and a mean PDI of 99.4 ( SD = 14.8). Infants with ( n = 71) and without ( n = 97) chorioamnionitis did not statistically differ either with mean MDI (91.8 vs. 90.3 points; p = 0.29) or mean PDI (98.3 vs. 100.9 points; p = 0.81), even after controlling for gestational age, mean APGAR scores and administration of antenatal steroids. Bronchopulmonary dysplasia was identified as the most influential factor for both MDI ( p = .024) and PDI ( p = .004). Conclusion We could not find an effect of chorioamnionitis on neurodevelopmental outcome of very preterm infants over an eleven‐year period. Analysis shows that postnatal factors have higher impacts than does chorioamnionitis.