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The challenge to define the optimal prophylactic regimen for vitamin K deficiency bleeding in infants
Author(s) -
Lembo Chiara,
Buonocore Giuseppe,
Perrone Serafina
Publication year - 2021
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15566
Subject(s) - medicine , prophylactic treatment , regimen , pediatrics , incidence (geometry) , vitamin k deficiency , vitamin k , vitamin , intramuscular injection , surgery , physics , optics
Infants are at risk of vitamin K deficiency that may lead to vitamin K deficiency bleeding (VKDB). Although many vitamin K prophylactic regimens have been developed throughout the years, still cases of late form VKBD may occur. The introduction of combined prophylactic strategy with prolonged oral prophylaxes after the intramuscular dose at birth has showed a decrease of the late severe VKDB incidence. Nevertheless, there is still lack of consensus about the administration scheme after the first dose at birth. Conclusion Late form VKBD is not eradicated, and the best prophylactic regimen in term and preterm infants is still an open debate.