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Pathogenesis of necrotising enterocolitis: The impact of the altered gut microbiota and antibiotic exposure in preterm infants
Author(s) -
Raba Ali Ahmed,
O'Sullivan Anne,
Miletin Jan
Publication year - 2021
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15559
Subject(s) - medicine , pathogenesis , antibiotics , necrotizing enterocolitis , enterocolitis , neonatal intensive care unit , gut flora , intensive care medicine , pediatrics , immunology , microbiology and biotechnology , biology
Necrotising enterocolitis (NEC) is a devastating condition with high morbidity and mortality seen predominately in preterm infants. Multiple factors are associated with the pathogenesis of NEC. The widespread use of antibiotics in the neonatal intensive care unit might play a role in the pathogenesis of NEC in preterm infants. This review provides a summary on the intestinal microbiota in preterm infants with a focus on how antibiotic exposure may reduce the biodiversity of the intestinal microbiota and may predispose preterm infants to NEC. Conclusion Prolonged antibiotic therapy has been suggested as a risk factor for the development of NEC in preterm infants.