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Introducing multi‐modal enteral medication reduced morbidity and mortality associated with necrotising enterocolitis
Author(s) -
Harutyunyan Arman,
Urlesberger Berndt,
Muradyan Armen,
Hovhannisyan Marine,
Badalyan Arman,
Kalenteryan Hrant,
Haxhija Emir,
Sargsyan Karine,
Yenkoyan Konstantin,
Babloyan Ara
Publication year - 2021
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15466
Subject(s) - medicine , enteral administration , regimen , perforation , necrotizing enterocolitis , pediatrics , enterocolitis , observational study , parenteral nutrition , surgery , punching , materials science , metallurgy
Aim Necrotising enterocolitis (NEC) is still a disease with high morbidity and mortality. The aim of the study was to analyse retrospectively whether the introduction of a multi‐modal three‐component enteral medication regimen resulted in a change in morbidity and mortality in neonates with NEC. Methods When diagnosis of NEC was established, the following multi‐modal three‐component enteral medication regimen was administered enterally (via nasogastric tube): an antibiotic, an antifungal agent and a probiotic. The primary outcome parameters were intestinal perforation, surgical interventions and mortality during the observational periods. Results In the study period, 2212 patients were admitted to the NICU, out of which 200 (9%) developed NEC. Significantly fewer infants died in the Intervention Group (13 of 104 infants, 13%) compared to the Control Group (38 of 96 infants, 40%) ( P =  .0001). No infant in the Intervention Group (0%) presented with an intestinal perforation, as compared to 15 infants (16%) within the Control Group ( P =  .0001). In the Control Group, 21 infants (22%) needed surgical intervention, whereas 0 (0%) infants needed this in the Intervention Group. Conclusion The introduction of an enteral multi‐modal three‐component medication regimen resulted in a significant reduction of mortality and of need for surgical intervention in infants suffering from NEC.

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