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Quality of life was similar in children with congenital diaphragmatic hernia and oesophageal atresia and related to respiratory morbidity
Author(s) -
Darmaun Laura,
Lejeune Stephanie,
Drumez Elodie,
Mur Sebastien,
LangleChevalier Fanny,
Nève Véronique,
Storme Laurent,
Michaud Laurent,
Gottrand Frederic,
Thumerelle Caroline,
Deschildre Antoine
Publication year - 2021
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15426
Subject(s) - medicine , congenital diaphragmatic hernia , pulmonary function testing , quality of life (healthcare) , pediatrics , atresia , pregnancy , fetus , genetics , nursing , biology
Aim To assess quality of life (QoL) in children with congenital diaphragmatic hernia (CDH) and to compare it with oesophageal atresia (OA). Methods A cross‐sectional study in CDH children (≥7 years) was conducted in Lille University Hospital, France, from January 2013 to April 2014. History, lung function (rest, exercise) and Pediatric Quality of Life Inventory questionnaires (PedsQoL 4.0) were collected. Data of OA children were previously published. Results Fifty‐four CDH patients (male: 53%, median age: 11 years, IQR 9‐14) were compared to 54 OA patients (male: 61%, median age: 13 years, IQR: 11‐15). CDH children had significantly more frequent history of pneumonia (30% vs 13%), exercise limitation (54% vs 35%) and chest deformity (39% vs 11%); 46% had an obstructive pattern and 66% an abnormal cardiopulmonary exercise test. The median PedsQoL total score in children was 81 (IQR 73‐90) in CDH and 81 (IQR 72‐91) in OA ( P = .8). In CDH, duration of neonatal oxygen therapy, hospitalisation for respiratory disease, exercise limitation, inhaled corticosteroids treatment, chest deformity, abnormal cardiopulmonary exercise test and lower forced expiratory volume in one second were significantly associated with lower QoL scores. Conclusion PedsQoL scores remained satisfactory in CDH children with CDH, with no difference compared to OA. Patients with respiratory morbidity and lung function impairment, who displayed lower scores, should be identified in order to optimise their management in reference centres.