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The utility of multichannel intraluminal impedance‐pH testing in tailoring the management of paediatric gastro‐oesophageal reflux disease
Author(s) -
Gunasagaran Hema Lattha,
Varjavandi Vincent,
Lemberg Daniel A.,
Ooi Chee Y.,
Gupta Nitin,
Krishnan Usha
Publication year - 2020
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15317
Subject(s) - medicine , reflux , referral , gastro , gastroenterology , disease , bolus (digestion) , esophageal ph monitoring , gerd , family medicine
Aim To determine whether combined multichannel intraluminal impedance and pH (MII‐pH) testing led to a change in management of children with gastro‐oesophageal reflux disease (GORD). Methods Retrospective chart review was done in all patients who underwent MII‐pH testing for GORD symptoms at Sydney Children's Hospital between 2008 and 2016. Changes to anti‐reflux medications and referral for anti‐reflux surgery were evaluated. Results There were 365 patients, 260 (71.2%) of whom were on acid‐suppressing therapy. The median age was 4.1 ± 4.8 years, 205 patients (56%) were males, 83 (22.7%) were infants (<1 year of age) and 145 (39.7%%) had comorbid conditions. We found 72.1% had abnormal MII‐pH results, of which 17.5% had abnormal acid reflux, 8.2% had abnormal number of retrograde bolus movements and 46.3% had hypersensitive oesophagus (positive symptom association only). Infants were significantly more likely to have abnormal MII‐pH results compared to older children ( P = .04). Results of MII‐pH testing led to medication changes in 44.7% and referral for anti‐reflux surgery in 6.8% of patients. Conclusion Combined multichannel intraluminal impedance and pH testing is clinically useful in the management of children with symptoms of GORD and over half the patients had changes to their medical treatment or referral for anti‐reflux surgery based on the results of MII‐pH testing. It resulted in a treatment change in an additional 32% of patients over traditional pH‐metry.