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The effects of proton pump inhibitors on the microbiome in young children
Author(s) -
Levy Elvira I.,
Hoang Delphine M.,
Vandenplas Yvan
Publication year - 2020
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15213
Subject(s) - medicine , dysbiosis , microbiome , adverse effect , intensive care medicine , clostridium difficile , necrotizing enterocolitis , proton pump inhibitor , enterocolitis , sepsis , population , immunology , pediatrics , gut flora , bioinformatics , microbiology and biotechnology , environmental health , biology , antibiotics
Aim The use of proton pump inhibitor (PPI) treatments are increasing among paediatric patients worldwide. We aimed to review the effects of PPIs on the microbiome and its associated effect on the gastrointestinal, respiratory and metabolic systems. The role of probiotics is discussed. Methods We searched for relevant articles published in English language in PubMed and Google Scholar. Articles were extracted using subject heading and key words of interest to the topic. Results There is evidence that PPIs modify the microbiome of the mouth, gut and lungs. The specific adverse effects associated with PPIs were necrotising enterocolitis, late onset sepsis in premature infants, Clostridium difficile infection, asthma, obesity and small intestine bacterial overgrowth in young children. Studies on the use of probiotics to counteract adverse effects of PPIs were limited. Conclusion PPIs create dysbiosis of the microbiome in the mouth, gut and lungs in the paediatric population. Probiotics could restore dysbiosis but it has very poorly been studied if probiotics can counteract or prevent PPI induced adverse effects.