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A single centre experience of treatment outcomes for Helicobacter pylori infection among inner‐city children and adolescents
Author(s) -
Mathews Jubin,
Malik Preeti,
Rai Anjali,
Lin Juan,
Kim Ryung S.,
Pan Debra H.
Publication year - 2020
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.15150
Subject(s) - medicine , clarithromycin , helicobacter pylori , metronidazole , amoxicillin , gastroenterology , regimen , proton pump inhibitor , antibiotics , population , microbiology and biotechnology , environmental health , biology
Aim This study assessed treatment outcomes of Helicobacter pylori ( H pylori ) infection among inner‐city children. Methods This was a retrospective study of patients aged 1‐21 years who underwent initial treatment for H pylori infection from 2011 to 2015. We included patients who completed 2 weeks of treatment with documented adequate compliance after H pylori infection was diagnosed. Treatment outcomes were measured based on stool H pylori antigen and/or histology. Results Of the total 261 patients diagnosed with H pylori , 239 completed the first‐line treatment. The regimens used included amoxicillin/clarithromycin/proton pump inhibitor (PPI) in 207/239 patients (86.6%), amoxicillin/metronidazole/PPI in 14/239 patients (5.8%) and other regimens in 18/239 patients (7.5%). H pylori eradication status was tested in 111/207 (53.6%) patients treated with amoxicillin/clarithromycin/PPI, and the eradication was achieved in 84/111(75.7%) patients. The treatment success rates for amoxicillin/metronidazole/PPI and other regimens were 71.4% (5/7) and 63.6% (7/11), respectively. There was no statistical significance of post‐treatment stool H pylori antigen results between PPI (n = 31) and no PPI (n = 43) users. Conclusion The study showed an eradication rate of 75.7% with the regimen amoxicillin/clarithromycin/PPI suggesting significant antibiotic resistance in our population. The use of PPI did not influence post‐treatment stool H pylori antigen results.