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High daily salt intake had a negative impact on how well nocturnal enuresis treatment worked on children aged 7‐10 years
Author(s) -
Tsuji Shoji,
Yamaguchi Tadashi,
Akagawa Yuko,
Akagawa Shohei,
Kino Jiro,
Yamanouchi Sohsaku,
Kimata Takahisa,
Kaneko Kazunari
Publication year - 2020
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14922
Subject(s) - enuresis , medicine , nocturnal , creatinine , urine , pediatrics , blood urea nitrogen , urinary system
Aim We investigated whether the daily salt intake of children with nocturnal enuresis influenced their response to 1‐desamino‐8‐D‐arginine vasopressin therapy. Methods This study comprised 129 children (67.4% boys) with a median age of 9.2 years (range 7.2‐10.4) with monosymptomatic nocturnal enuresis who were seen at Kansai Medical University Hospital, Osaka, Japan, from 2013 to 2017. Urinary sodium concentrations were determined using a spot urine test, and the children were divided into appropriate (n = 55) and excessive salt intake (n = 74) groups based on Japanese Government guidelines. After a month of therapy, the treatment responses were compared for 39 and 50 children, respectively. Results There were no significant differences in the urea nitrogen‐to‐creatinine or calcium‐to‐creatinine ratios in the two groups. However, the excessive salt intake group showed a significantly reduced treatment response to the appropriate salt intake group. In addition, the excessive and appropriate salt intake groups showed median efficacy ratios of 8.2% and 21.8%, respectively, based on intention‐to‐treat analysis ( P = 0.029) and 12.0% and 30.8% based on per‐protocol analysis ( P = 0.029). Conclusion High daily salt intake significantly reduced the efficacy of ddavp therapy for nocturnal enuresis and consumption should be controlled during treatment.