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Cognitive outcome of early school‐aged children born very preterm is not predicted by early short‐term amplitude‐integrated electroencephalography
Author(s) -
Feldmann Maria,
Rousson Valentin,
Nguyen Thi Dao,
Bernet Vera,
Hagmann Cornelia,
Latal Beatrice,
Natalucci Giancarlo
Publication year - 2020
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14919
Subject(s) - medicine , pediatrics , gestational age , intelligence quotient , univariate analysis , prospective cohort study , cognition , cohort , confounding , birth weight , multivariate analysis , pregnancy , psychiatry , genetics , biology
Aim We investigated the association between early amplitude‐integrated electroencephalography (aEEG) and cognitive outcome in very preterm infants at early school‐age. Methods This prospective cohort study, conducted in the Department of Neonatology, University Hospital Zurich, Switzerland, from 2009 to 2012, comprised of infants born at <32 weeks of gestation, who underwent continuous aEEG recording during the first 4 days of life. Cognitive outcome was assessed with the Kaufman‐Assessment Battery for Children at 5 years. Univariate and multivariate logistic regressions were calculated between aEEG parameters and normal cognitive outcome, defined as an intelligence quotient (IQ) of at least 85. Results The 118 (52.5% male) infants were born at a mean gestational age of 29.9 weeks and a mean birth weight of 1235 ± 363 g. We followed up 89 children at the age of five, and they had a mean IQ of 97.8 ± 12.7 with 21.3% under 85—and 2.2% had cerebral palsy. Univariate analyses found associations between aEEG measures and normal cognitive outcome, but these were no longer significant after adjustment for confounders. Socioeconomic status and neonatal morbidity were independent predictors of cognitive outcome. Conclusion Early short‐term aEEG did not predict later cognitive outcome in our cohort of very preterm infants.