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Effects of growth hormone therapy on metabolic parameters, adipokine and endothelial dysfunction in prepuberal children
Author(s) -
Cañete María Dolores,
ValleMartos Rosario,
Martos Rosario,
Cañete Ramón,
Valle Miguel,
JiménezReina Luis
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14849
Subject(s) - medicine , adipokine , endocrinology , adiponectin , insulin resistance , leptin , insulin , lipid profile , cholesterol , obesity
Aim To determine whether non‐obese prepubertal children with growth hormone deficiency (GHD) present changes in lipid metabolism, and adipokines, and to assess the short‐term effects of growth hormone (GH) treatment on these parameters. Methods Prospective observational follow‐up and case–control (36 GHD children and 38 healthy children) study lasted for six months. Means of values from groups were compared, control group versus GHD baseline group, and GHD baseline group versus GHD after six months of GH replacement therapy. Lipid profile, glucose, insulin, homeostatic model assessment – insulin resistance (HOMA‐IR), leptin, adiponectin and soluble intercellular adhesion molecule‐1 (sICAM‐1) were all analysed. Results Growth hormone deficiency children show higher baseline levels of total cholesterol, LDL cholesterol, triglycerides, Apo B and sICAM‐1, but lower levels of free fatty acids, insulin and HOMA‐IR. After six months of treatment, cholesterol, LDL cholesterol, Apo B, T cholesterol/HDL cholesterol, insulin, HOMA‐IR and leptin levels decreased. The changes in insulin and HOMA‐IR levels correlated inversely with the changes in HDL cholesterol and Apo A1 levels. A correlation was also observed between the changes in adiponectin levels and the changes in HDL cholesterol and Apo A1 levels. Variations in leptin levels were correlated with changes in triglycerides. Conclusion Prepubertal non‐obese GHD children present altered lipid profiles and adipokine levels. Replacement therapy with GH improves these variables.