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Cord blood fatty acid‐binding protein‐4 levels are upregulated at both ends of the birthweight spectrum
Author(s) -
Papathanasiou Aimilia Eirini,
Briana Despina D.,
Gavrili Stavroula,
Georgantzi Sophia,
Papathoma Evangelia,
Marmarinos Antonios,
Christou Christos,
Voulgaris Konstantinos,
Gourgiotis Dimitrios,
MalamitsiPuchner Ariadne
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14826
Subject(s) - medicine , cord blood , gestational age , fatty acid binding protein , obstetrics , offspring , birth weight , fetus , population , cord , pregnancy , endocrinology , physiology , surgery , biology , biochemistry , genetics , environmental health , gene
Aim Fatty acid‐binding protein‐4 (FABP4) is an adipokine associated with obesity and signs of the metabolic syndrome. We aimed to investigate at birth in term neonates with normal and abnormal intrauterine growth concentrations of FABP4 and associate them with various perinatal parameters. Methods Serum cord blood FABP4 levels were prospectively determined by ELISA in 80 singleton term appropriate‐for‐gestational‐age (AGA), intrauterine growth‐restricted (IUGR) and large‐for‐gestational‐age (LGA) neonates. Results Compared to the AGA group, cord blood FABP4 levels were increased in the IUGR and LGA groups. Additionally, they were higher in early‐term than full‐term neonates. A significant U‐shaped correlation was recorded between serum FABP4 levels and birthweight. A significant negative correlation between cord blood FABP4 and gestational age in the whole study population was noted. Conclusion Cord blood FABP4 levels were significantly higher at the extremes of foetal growth at term and negatively correlated with gestational age, being increased in early‐term versus full‐term neonates. Further longitudinal studies with larger sample sizes are required to elucidate FABP4 implication in foetal growth and its association with future adverse cardiometabolic outcomes in the offspring.