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Early‐life exposure to common virus infections did not differ between coeliac disease patients and controls
Author(s) -
Simre Kärt,
Uibo Oivi,
Peet Aleksandr,
Puustinen Leena,
Oikarainen Sami,
Tamminen Kirsi,
Blazevic Vesna,
Tillmann Vallo,
Hämäläinen AnuMaaria,
Härkönen Taina,
Siljander Heli,
Virtanen Suvi M.,
Ilonen Jorma,
Hyöty Heikki,
Knip Mikael,
Uibo Raivo
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14791
Subject(s) - medicine , coeliac disease , rhinovirus , enterovirus , antibody , virus , immunology , disease , poliovirus , gastroenterology , virology
Aim Our aim was to compare the presence of various common viruses (rhinovirus, enterovirus, adenovirus, Epstein–Barr virus, cytomegalovirus, norovirus, parechovirus) in stool and nasal swab samples as well as virus‐specific antibodies in serum samples between children who developed coeliac disease and controls. Methods A case–control study was established based on the DIABIMMUNE Study cohorts. During the study, eight Estonian children and 21 Finnish children aged 1.5 years to five years developed coeliac disease and each was matched with a disease‐free control. Nasal swabs and stool samples were taken at the age of three to six months and the serum samples at the time of diagnosis. Results Rhinovirus ribonucleic acid was detected in the nasal swabs from five coeliac disease children, but none of the control children (p = 0.05). There were no statistically significant differences in the level of viral antibodies between cases and controls. Enterovirus immunoglobulin G class antibodies were found more frequently in the Estonian than in the Finnish children (63% versus 23%, p = 0.02). Conclusion This study did not find any marked overall differences in laboratory‐confirmed common viral infections between the children who developed coeliac disease and the controls. However, rhinovirus infections were detected slightly more often in those patients who developed coeliac disease.