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Increased risk of hemangioma after exposure to neonatal phototherapy in infants with predisposing risk factors
Author(s) -
Auger Nathalie,
Ayoub Aimina,
Lo Ernest,
Luu Thuy Mai
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14727
Subject(s) - medicine , hemangioma , hazard ratio , confidence interval , pediatrics , gestation , incidence (geometry) , cohort , infantile hemangioma , cohort study , gestational age , obstetrics , pregnancy , surgery , physics , biology , optics , genetics
Aim To determine the relationship between neonatal phototherapy and future risk of clinically significant hemangioma. Methods We analysed a cohort of 678 879 infants born after 34 weeks gestation comprising 3 975 242 person‐years of follow‐up over 11 years (2006–2016). The exposure was phototherapy the first 28 days of life. The outcome was hemangioma that required in‐hospital treatment during follow‐up. We estimated hazard ratios (HR) and 95% confidence intervals (CI) for the association of phototherapy with risk of hemangioma, accounting for preterm birth, low birthweight and congenital anomalies. Results The incidence of hemangioma was greater in neonates who received phototherapy than in untreated infants, but there was no association in adjusted models (HR 1.19, 95% CI 0.89–1.58). Risk of hemangioma was elevated in infants who received phototherapy and were born late preterm (HR 2.35, 95% CI 1.51–3.64), with low birthweight (HR 1.91, 95% CI 1.12–3.24), or with anomalies (HR 5.09, 95% CI 3.42–7.58). Without phototherapy, these three risk factors were more weakly associated with hemangioma. Conclusion Neonatal phototherapy in infants with predisposing risk factors may increase the chance of hemangioma, but confirmation in further studies is needed.