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Model that predicted death or disabilities in premature infants was valid at seven years of age
Author(s) -
Piris Borregas Salvador,
Torres Valdivieso María José,
MartínArriscado Cristina,
Cruz Bértolo Javier,
Sierra García Purificación,
Pallás Alonso Carmen Rosa
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14679
Subject(s) - medicine , retinopathy of prematurity , bronchopulmonary dysplasia , pediatrics , confidence interval , odds ratio , retrospective cohort study , neonatal intensive care unit , birth weight , logistic regression , cohort study , cohort , gestational age , surgery , pregnancy , genetics , biology
Aim Validated a model that used bronchopulmonary dysplasia ( BPD ), brain injuries measured using ultrasound and retinopathy of prematurity ( ROP ) to predict late death or disability in premature infants at seven years of age. Methods A retrospective study was performed at the 12 de Octubre Hospital neonatal unit in Madrid. A logistic model was applied to estimate the independent prognostic contribution of each morbidity, and the effect that the combination of morbidities had on the seven‐year outcomes. The analysis was performed on the total cohort from 1991 to 2008 and on two subcohorts from 1991 to 1998 and 1999 to 2008. Results A total of 1001 children were included with a mean birth weight of 922 ± 208 g. Severe ROP was strongly associated with poor neurodevelopment, with an odds ratio ( OR ) 3.17 and 95% confidence interval ( CI ) of 1.56–6.50, and so was BPD ( OR 1.52, 95% CI : 1.03–2.2). The combination of two neonatal morbidities increased the risk of a poor outcome ( OR 4.44, 95% CI : 1.51–7.86). The model behaved differently in the two subcohorts. Conclusion The prognostic model predicted a poor outcome at seven years of age when the subjects had at least two of the three morbidities.