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Algorithm for predicting threshold retinopathy of prematurity is insufficient and fundus examinations are still needed before 31 weeks
Author(s) -
Wirth M,
Naud A,
Caputo G,
Hascoët J M
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14654
Subject(s) - medicine , retinopathy of prematurity , gestational age , birth weight , neonatal intensive care unit , pediatrics , apgar score , predictive value , fundus (uterus) , retrospective cohort study , cohort , gestation , ophthalmology , obstetrics , pregnancy , surgery , genetics , biology
Abstract Aim We evaluated the weight, insulin‐like growth factor‐1, neonatal, retinopathy of prematurity ( WINROP ) algorithm for very premature infants. Method Infants born before 32 weeks who had undergone fundus examinations in the neonatal intensive care unit at the University Hospital of Nancy were included in this French retrospective cohort study from July 2012 to July 2016. We evaluated how well the WINROP software predicted threshold retinopathy of prematurity ( ROP ). Results We studied 570 infants with a mean gestational age of 28.7 ± 1.8 weeks and a mean birth weight of 1110 ± 297 g: 28.1% had ROP and 1.2% had threshold ROP . The overall WINROP sensitivity was 57.1%, specificity was 46.0%, predictive positive value was 1.3% and predictive negative value was 98.9%. At more than 30 weeks of gestation or 1250 g, these figures rose to a respective specificity of 100% and 95.7% and respective predictive negative value of 100% and 100%. There were independent associations between the severity of ROP and the Apgar score at five minutes, the duration of oxygen therapy and non‐invasive ventilation. Conclusion WINROP worked better on preterm infants born from 31 weeks onwards or weighing over 1250 g. Fundus examinations remain necessary for infants born earlier or lighter.