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The gut microbiota of hand, foot and mouth disease patients demonstrates down‐regulated butyrate‐producing bacteria and up‐regulated inflammation‐inducing bacteria
Author(s) -
Li Weiran,
Zhu Yu,
Li Yiyuan,
Shu Min,
Wen Yang,
Gao Xiaolin,
Wan Chaomin
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14644
Subject(s) - bacteria , medicine , butyrate , inflammation , gut flora , hand foot and mouth disease , microbiology and biotechnology , disease , immunology , pathology , biology , food science , genetics , fermentation
Aim This study explored the gut microbiota of children with hand, foot and mouth disease ( HFMD ). Methods We enrolled 15 cases with HFMD admitted to the West China Second Hospital, Sichuan University, China, from July to September 2016 at a median age of three years. The controls were 15 healthy children of a similar age who underwent routine health examinations at the hospital during the same period. Gut microbiota was analysed using high throughput 16S ribosomal deoxyribonucleic acid sequencing. Results The gut microbiota in the HFMD patients was distinct from the controls. Compared with the controls, the composition of gut microbiota in the HFMD cases represented a reduction of two butyrate‐producing bacteria, Ruminococcus (0.73 ± 1.28 versus 7.78 ± 20.01, p = 0.026) and Roseburia (0.67 ± 1.69 versus 1.61 ± 3.27, p = 0.024) and an up‐regulation of Escherichia (5.26 ± 10.50 versus 1.59 ± 5.90,p < 0.01) and Enterococcus (4.12 ± 12.49 versus 0.12 ± 0.41, p = 0.015). Conclusion The dysbiosis of gut microbiota of the HFMD cases included a reduction of butyrate‐producing bacteria and an up‐regulation of inflammation‐inducing bacteria. These may have impaired the intestinal biological mucosal barrier and host immune functions, promoting the invasion of the enterovirus.