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Effect of early probiotic supplementation on childhood cognition, behaviour and mood a randomised, placebo‐controlled trial
Author(s) -
Slykerman R F,
Kang J,
Van Zyl N,
Barthow C,
Wickens K,
Stanley T,
Coomarasamy C,
Purdie G,
Murphy R,
Crane J,
Mitchell E A
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14590
Subject(s) - medicine , neurocognitive , placebo , lactobacillus rhamnosus , breastfeeding , mood , randomized controlled trial , pediatrics , probiotic , placebo controlled study , bifidobacterium animalis , anxiety , cognition , psychiatry , bifidobacterium , lactobacillus , double blind , alternative medicine , pathology , biology , bacteria , genetics
Aim To determine whether probiotic supplementation in early life improves neurocognitive outcomes assessed at 11 years of age. Methods A total of 474 children who were born March 2004–Aug 2005 participated in a two‐centre randomised placebo‐controlled trial of infants at risk of developing allergic disease. Pregnant women were randomised to take Lactobacillus rhamnosus strain HN001, Bifidobacterium animalis subsp. lactis strain HN019 or placebo daily from 35 weeks gestation until six months if breastfeeding, and their infants the same treatment from birth to two years. Intelligence, executive function, attention, depression and anxiety were assessed when the children were 11 years of age. Results A total of 342 (72.2%) children were assessed (HN001 n = 109, HN019 n = 118 and placebo n = 115). Overall, there were no significant differences in the neurocognitive outcomes between the treatment groups. Conclusion HN001 and HN019 given in early life were not associated with neurocognitive outcomes at 11 years of age in this study. However, we cannot exclude that other probiotics may have a beneficial effect. Further clinical trials are indicated.