Premium
Prospective study confirms that bronchiolitis in early infancy increases the risk of reduced lung function at 10–13 years of age
Author(s) -
Riikonen Riikka,
Lauhkonen Eero,
Törmänen Sari,
Backman Katri,
Koponen Petri,
Helminen Merja,
Nuolivirta Kirsi,
Korppi Matti
Publication year - 2019
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14412
Subject(s) - medicine , bronchiolitis , lung function , prospective cohort study , pediatrics , lung , respiratory system
Aim This study evaluated children hospitalised for bronchiolitis at less than six months of age to see if they had reduced lung function in early adolescence. Methods We have prospectively followed 166 children hospitalised for infant bronchiolitis in 2001–2004 at Tampere University Hospital, Finland. At 10–13 years of age, flow‐volume spirometry was measured in 89 cases and 108 controls without infant bronchiolitis from the local population register. Parameters of flow‐volume spirometry before and after bronchodilation were analysed. Results Forced expiratory volume in one second/forced vital capacity ( FEV 1/ FVC ) after bronchodilation was lower in cases than controls. FEV 1 was pathological – under the 5th percentile of the national references – in 25% of cases and 12% of controls (p = 0.020) before bronchodilation and in 18% of cases and 5% of controls (p = 0.003) after bronchodilation. FEV 1/ FVC was pathological in 25% of cases and 13% of controls (p = 0.034) before bronchodilation. Logistic regression, adjusted for current asthma and maternal smoking, showed that infant bronchiolitis was associated with pathological FEV 1 before (odds ratio 2.4) and after (odds ratio 4.4) bronchodilation. The result was similar for positive respiratory syncytial virus cases. Conclusion Reduced FEV 1 after bronchodilation was found in early adolescence after infant bronchiolitis, suggesting irreversible bronchial obstruction.