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Outpatients with acute osteoarticular infections had favourable outcomes when they received just oral antibiotics without intravenous antibiotics
Author(s) -
Alcobendas Rosa,
Remesal Agustín,
Murias Sara,
Nuñez Esmeralda,
Calvo Cristina
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14373
Subject(s) - medicine , antibiotics , septic arthritis , intravenous antibiotics , prospective cohort study , osteomyelitis , arthritis , surgery , microbiology and biotechnology , biology
Aim The traditional approach for acute paediatric osteoarticular infections (OAI) has comprised initial intravenous antibiotics followed by prompt oral antibiotics. We assessed how providing just oral antibiotics compared to the traditional two‐step approach. Methods This prospective study was performed at the Hospital La Paz, Madrid, Spain, from September 2015 to September 2016. We compared 25 outpatients, with good general health and a mean age of 25 months who received just oral antibiotics, with 228 hospitalised children of a similar age who received intravenous and oral antibiotics from other hospitals in the Spanish Network of Osteoarticular Infections. Results The groups were comparable in terms of age, sex, fever, erythrocyte sedimentation rate value, C‐reactive protein and diagnosis. The oral group comprised 15 with osteomyelitis, seven with septic arthritis, two with osteoarthritis and one with spondylodiscitis. This group had a lower percentage of Staphylococcus aureus (8% vs 26%, p = 0.06) and higher proportion of Kingella kingae (24% vs 9%, p = 0.017) than the intravenous group. There were complications (24%) and follow‐up sequelae (6%) in the intravenous group, but none in the oral group. Conclusion Outpatients with OAI who were in good general health had favourable outcomes when they received oral antibiotics without intravenous antibiotics.