Premium
The five‐year survival of children with Down syndrome in Norway 1994–2009 differed by associated congenital heart defects and extracardiac malformations
Author(s) -
Brodwall Kristoffer,
Greve Gottfried,
Leirgul Elisabeth,
Klungsøyr Kari,
Holmstrøm Henrik,
Vollset Stein Emil,
Øyen Nina
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14223
Subject(s) - medicine , hazard ratio , down syndrome , pediatrics , cohort , population , hypoplastic left heart syndrome , atresia , congenital malformations , norwegian , heart disease , pregnancy , confidence interval , linguistics , philosophy , environmental health , psychiatry , biology , genetics
Aim We investigated the prevalence of Down syndrome in a nationwide birth cohort, focusing on congenital heart defects (CHDs), their associations with extracardiac malformations (ECM) and survival. Methods National registers were used to identify Norwegian births (1994–2009) and deaths (1994–2014) and updated with hospital diagnoses. We estimated birth defect frequencies in Down syndrome and the general population, the association between CHDs and ECM and hazard ratios for death from different combinations of CHDs and ECM. Results Down syndrome was found in 1672 of 953 450 births (17.6 per 10 000). Of the 1251 live births (13.3 per 10 000), 58% had CHD and 9% ECM. CHDs were associated with oesophageal atresia (p = 0.02) and Hirschsprung's disease (p = 0.03) but with no other malformations. The five‐year survival for Down syndrome increased from 91.8% (1994–1999) to 95.8% (2000–2009) (p = 0.006), and overall survival was 92.0% with CHD and 97.4% without. Compared with Down syndrome children without CHD or ECM, the five‐year mortality was similar for those with nonsevere CHDs, without or with ECM, but 4–7 times higher in those with severe CHDs without ECM and 13–28 times higher in those with severe CHDs and ECM. Conclusion Down syndrome childhood survival improved, but mortality remained high with severe CHDs and extracardiac defects.