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The changing relationship between bronchopulmonary dysplasia and cognition in very preterm infants
Author(s) -
Brumbaugh Jane E.,
Colaizy Tarah T.,
Patel Neel M.,
Klein Jonathan M.
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14219
Subject(s) - bronchopulmonary dysplasia , medicine , cognition , pediatrics , intensive care medicine , gestational age , psychiatry , pregnancy , genetics , biology
Aim To characterise the relationship between bronchopulmonary dysplasia ( BPD ) severity and cognition in the post‐surfactant era. Methods This was a single‐centre retrospective analysis of a cohort of infants born 2009–2012. Inclusion criteria were as follows: admission within 48 hours of birth, gestational age 22‐0/7–31‐6/7 weeks, birthweight 400–1500 g and Bayley Scales of Infant and Toddler Development‐ III testing at 18–26 months corrected age. Infants (n = 151) were classified by BPD severity with the NIH Workshop definition. Generalised linear modelling and multivariate logistic regression were performed. Results Bayley cognitive score was not associated with BPD severity in univariate (p = 0.053) or multivariate (p = 0.503) analysis. About 27% of infants with no/mild BPD , 33% of infants with moderate BPD and 40% of infants with severe BPD had a cognitive score <85. There was no difference in the odds of cognitive score <85 based on BPD severity in univariate (p = 0.485) or multivariate analysis (p = 0.225). All infants with cognitive score <70 had severe BPD , although the association between cognitive score <70 and BPD severity was not significant. Conclusion We found no independent effect of BPD severity level on cognition. The likelihood of a cognitive score <85 was not associated with BPD severity.