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Repeated doses of salbutamol and aeroallergen sensitisation both increased salbutamol‐induced hypoxia in children and adolescents with acute asthma
Author(s) -
Ozer Murat,
Buyuktiryaki Betul,
Sahiner Umit Murat,
Teksam Ozlem,
Karaatmaca Betul,
Soyer Ozge,
Sekerel Bulent Enis
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14202
Subject(s) - salbutamol , medicine , asthma , hypoxia (environmental) , anesthesia , pulse oximetry , aeroallergen , allergy , allergen , immunology , oxygen , chemistry , organic chemistry
Aim We aimed to identify the frequency, magnitude and risk factors of salbutamol‐induced hypoxia in children with acute asthma. Methods This study was conducted at Hacettepe University on children who presented to the paediatric allergy clinic or the paediatric emergency room with acute asthma between July 2014 and June 2015. Vital signs, pulse oximetry‐defined oxygen saturation and modified pulmonary index scores were evaluated before and after the first, second and third doses of nebulised salbutamol and repeated one and 10 days later. Results We included 304 patients (65.7% male) from median age of 5.3 years (range 1–18 years). Salbutamol‐induced hypoxia was detected in 14.7%, 3.9% and 1.3%, respectively, after the first, second and third doses of salbutamol. The risk factors for hypoxia were younger age and a higher modified pulmonary index score, but the risk factors for salbutamol‐induced hypoxia were the number of salbutamol doses given in the last six hours and the presence of aeroallergen sensitisation. The maximum decrease in oxygen saturation after salbutamol was %5. Conclusion Although bronchodilators are the first‐line treatment for acute asthma, they caused modest hypoxaemia, especially at repeated doses and, or, in patients with aeroallergen sensitisation.