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Review demonstrates that less invasive surfactant administration in preterm neonates leads to fewer complications
Author(s) -
Gortner Ludwig,
Schüller Simone S.,
Herting Egbert
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14161
Subject(s) - medicine , bronchopulmonary dysplasia , continuous positive airway pressure , pulmonary surfactant , respiratory distress , bradycardia , anesthesia , airway , lung , intensive care medicine , heart rate , blood pressure , gestational age , pregnancy , genetics , physics , obstructive sleep apnea , biology , thermodynamics
Surfactant treatment of neonatal respiratory distress syndrome ( RDS ) was introduced in Europe during the 1990s. Meta‐analyses have indicated that using less invasive surfactant administration techniques on preterm neonates receiving continuous positive airway pressure ( CPAP ) results in improved survival rates without bronchopulmonary dysplasia. Surfactant should be administered early and ventilator settings adapted to changing oxygen requirements and lung mechanics. Side effects including initial bradycardia, oxygen desaturation, tube obstruction and isolated cases of pulmonary haemorrhage have been reported. Conclusion Less invasive surfactant therapy improves pulmonary outcomes in preterm neonates with RDS and should ideally be administered in combination with CPAP .