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Functional variants in intercellular adhesion molecule‐1 and toll‐like receptor‐4 genes are more frequent in children with febrile urinary tract infection with renal parenchymal involvement
Author(s) -
Hussein Almontaser,
Saad Khaled,
Askar Eman,
Zahran Asmaa M.,
Farghaly Hekma,
Metwalley Kotb,
Elderwy Ahmad A.
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14118
Subject(s) - medicine , urinary system , genotype , intercellular adhesion molecule 1 , odds ratio , single nucleotide polymorphism , allele , immunology , icam 1 , gene , toll like receptor , parenchyma , receptor , gastroenterology , cell adhesion molecule , pathology , biology , genetics , innate immune system
Aim We studied the functional polymorphisms of intercellular adhesion molecule‐1 (ICAM‐1) and toll‐like receptor‐4 (TLR‐4) genes and risk of acute pyelonephritis (APN) in children attending Assiut University Children's Hospitals, Egypt, from 2011 to 2015. Methods Urinary tract infections ( UTI s) were diagnosed in 380 children: 98 had APN and 282 had lower UTI s. Four single‐nucleotide polymorphisms in ICAM‐1 and TLR‐4 genes were genotyped in all subjects: ICAM ‐1 rs1799969 Gly241Arg, ICAM ‐1 rs5498 Glu469Lys, TLR ‐4 rs4896791 Thr399Ile and TLR ‐4 rs4896790 Asp299Gly. Results Patients with APN were significantly more likely to have AA genotype of the ICAM ‐1 rs5498 (1462 A/G) polymorphism (p = 0.04) than children with lower UTI s and the TLR ‐4 Asp299Gly GG genotype (p = 0.002) and G allele (p = 0.006) than healthy controls. The association with the ICAM ‐1 Glu469Lys (1462A/G) was less evident. The GG genotype was associated with a modest relative risk of 1.4 (p = 0.1) of developing APN, but was not an independent odds ratio, at 1.2 (p = 0.48). Conclusion Functional variants in ICAM‐1 and TLR‐4 genes were increasingly common in children with febrile UTI s with renal parenchymal involvement, but the ICAM ‐1 Glu469Lys (1462A/G) association was less evident. TLR 4 Asp299Gly might independently increase renal parenchymal infection rather than renal scarring.