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Elevated serum adipsin may predict unsuccessful treatment for cows’ milk allergy but other biomarkers do not
Author(s) -
Salmivesi Susanna,
Paassilta Marita,
Huhtala Heini,
Nieminen Riina,
Moilanen Eeva,
Korppi Matti
Publication year - 2018
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14117
Subject(s) - medicine , resistin , adipokine , allergy , eosinophil , adiponectin , eosinophil cationic protein , immunology , leptin , gastroenterology , asthma , obesity , insulin resistance
Aim This study evaluated whether 15 allergy, immunology or inflammatory markers predicted the long‐term use of cows’ milk or milk products seven years after the start of oral immunotherapy ( OIT ) for cows’ milk allergy in children. Methods The following laboratory parameters were measured before the OIT at Tampere University Hospital, Finland, and after the six‐month escalation phase: serum total immunoglobulin (Ig) E, milk‐specific IgG and IgG4, eosinophil cationic protein, eosinophil‐derived neurotoxin, interleukins 4, 5, 6, 10 and 12p70 and serum adipokines adiponectin, adipsin, leptin and resistin. Follow‐up data from a seven‐year phone questionnaire in 2015 were available for 24 children: 14 successful and 10 unsuccessful milk users. Results There were no significant differences in any of the 15 markers measured at the start of the study between the subjects who later formed the successful and unsuccessful groups. At the end of the six‐month escalation phase of OIT , serum adipsin was higher in the group who were unsuccessful milk users at the seven‐year follow‐up study. Conclusion None of the 15 allergy, immunology or inflammatory markers were useful in predicting the outcome of OIT . Preliminary evidence was found that high serum adipsin after the six‐month escalation phase of OIT might predict unsuccessful outcome.