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Serum levels of omentin‐1 are increased after weight loss and are particularly associated with increases in obese children with metabolic syndrome
Author(s) -
Zhang Meizhen,
Tan Xinrui,
Yin Chunyan,
Wang Li,
Tie Yingchun,
Xiao Yanfeng
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14026
Subject(s) - medicine , metabolic syndrome , adipokine , insulin resistance , waist , obesity , body mass index , endocrinology , anthropometry , weight loss
Aim There have been very few paediatric studies on omentin‐1, an anti‐inflammatory adipokine that provides a link between adiposity, insulin resistance and metabolic syndrome. This Chinese study evaluated the association between omentin‐1 and metabolic syndrome and analysed the effect of a six‐month lifestyle intervention on the levels in obese children. Methods We recruited 119 obese outpatients (75% boys) aged 7–18 years from the Second Affiliated Hospital of Xi'an Jiaotong University, who underwent a six‐ month lifestyle intervention. Our controls were 55 matched children with normal weight. Anthropometric parameters, biochemical data and circulating omentin‐1 levels were measured at baseline and after six months. Results Of the 119 obese children, 32 (27%) had metabolic syndrome. The obese children, particularly those with metabolic syndrome, had significantly lower serum omentin‐1 levels at baseline than the controls. We also found that the omentin‐1 levels were negatively associated with their body mass index, waist circumference and homoeostasis model assessment of insulin resistance. After the six‐month lifestyle intervention, the obese children showed significant weight loss and their omentin‐1 levels increased. Conclusion Serum omentin‐1 was regulated by weight and seemed to be associated with children's metabolic disorders. A six‐month lifestyle intervention significantly increased serum omentin‐1 levels.