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Interleukin 17A gene polymorphism rs2275913 is associated with osteitis after the Bacillus Calmette‐Guérin vaccination
Author(s) -
LiehuMartiskainen Milla,
Korppi Matti,
Teräsjärvi Johanna,
Vuovirta Juho,
Huhtala Heini,
Nuolivirta Kirsi,
Kröger Liisa,
Peltola Ville,
Pöyhönen Laura,
He Qiushui
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.14000
Subject(s) - medicine , osteitis , genotype , immunology , vaccination , minor allele frequency , allele frequency , gene , genetics , biology , osteomyelitis
Aim Interleukin‐17 ( IL ‐17) appears to promote the host's defence against mycobacterial infections. This study evaluated the association between IL 17A gene polymorphism and the risk of Bacillus Calmette‐Guérin ( BCG ) osteitis after newborn vaccination and between IL 17A gene polymorphism and IL ‐17A concentrations in serum. Methods IL 17A rs2275913 gene polymorphisms and serum IL ‐17A concentrations were studied in 132 adults aged 21–49 years from across Finland, who had BCG osteitis in infancy after a newborn BCG vaccination. The subjects were recruited in 2007–2008, and their whole‐blood samples were sent to the National Institute for Health and Welfare, Turku, Finland. Their genotypes and minor allele frequencies were compared with 405 population‐based unvaccinated controls aged two to three months from a prospective birth cohort study. Results The genotypes and allele frequencies of IL 17A rs2275913 differed significantly between the former BCG osteitis patients and controls. The genotype was variant in 75.8% of cases and 64.0% of controls (p = 0.012), and the minor allele frequency was 50.0% in the cases and 41.6% of the controls (p = 0.009). Serum IL ‐17 concentrations did not differ significantly between the cases with wild or variant genotypes. Conclusion IL 17A rs2275913 gene polymorphism was associated with a risk of BCG osteitis after vaccination.