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Adipokines played a limited role in predicting temporary growth differences between very low birthweight infants with and without bronchopulmonary dysplasia
Author(s) -
Lehtinen A,
Korhonen P,
Hyödynmaa E,
Koivisto AM,
Peltola T,
Hämäläinen M,
Moilanen E,
Tammela O
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13942
Subject(s) - bronchopulmonary dysplasia , medicine , adipokine , gestational age , pediatrics , birth weight , low birth weight , body mass index , small for gestational age , leptin , pregnancy , obesity , genetics , biology
Aims This study explored whether growth was poorer among very low birthweight (VLBW) infants with bronchopulmonary dysplasia (BPD) and assessed adipokine levels as predictors of early growth. Methods We studied 53 VLBW infants born in Tampere University Hospital up to 12 months of corrected age (CA). The median gestational age of the 21 infants with BPD and 32 infants without BPD was 29 weeks, and the median birthweights were 930 (635–1470) and 1185 (650–1470) grams. Growth parameters, macronutrients intake and plasma levels of adipokines were measured. Results Bronchopulmonary dysplasia infants were lighter than controls until 36 weeks of CA, with catch‐up growth achieved by three months of CA. Adipsin levels were lower in BPD infants at 28 days of postnatal age. High leptin levels seemed protective for low weight for height at nine months of CA. The duration of ventilator therapy predicted low weight for height, length for age and body mass index and BPD predicted low length for age at 12 months of CA. Conclusions Catch‐up growth in VLBW infants with BPD was achieved by three months of CA, but adipokines played a limited role in predicting growth. Shortening ventilator therapy could help growth in VLBW infants.