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Using a spontaneous profile rather than stimulation test makes the KIGS idiopathic growth hormone deficiency model more accessible for clinicians
Author(s) -
Duchén Karel,
Lindberg Anders,
Kiplok Kaire,
Kriström Berit
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13932
Subject(s) - ighd , medicine , growth hormone , stimulation , growth hormone deficiency , growth model , growth hormone treatment , pediatrics , endocrinology , hormone , economics , microeconomics
Aim Children treated with a growth hormone ( GH ) for idiopathic growth hormone deficiency ( IGHD ) may be monitored with the first‐year prediction model from the Pfizer International Growth Database ( KIGS ) using auxology, age, GH dose and the maximum GH concentration from a stimulation test ( GH max stim). We tested the hypothesis that using a 12‐hour spontaneous profile ( GH max 12h) would be as accurate. Methods We studied 98 prepubertal Swedish children (78 boys) aged 2–12 years enrolled in KIGS . The first‐year growth was predicted using the GH max from the GH profile and a stimulation test, and both of these were compared separately with the observed growth response. Results The increased height observed in the first year was 0.74 standard deviation scores ( SDS ), and the studentised residuals for the predicted and observed growth with GH max stim (−0.16 SDS ) and GH max 12h (−0.22) were similar. Individual predictions calculated with stimulated or spontaneous GH max showed a significant correlation (r = 0.80). Conclusion We validated the KIGS IGHD prediction model and found that the stimulated GH max peak can be reliably replaced by the GH max 12h with similar accuracy. This makes the model more accessible for clinicians, who can then provide realistic expectations for the growth response during the first year of treatment.