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Determining normal values of urinary phosphorus excretion in 3913 healthy children aged 2–18 to aid early diagnosis and treatment for urolithiasis
Author(s) -
TarantaJanusz Katarzyna,
Łabieniec Łukasz,
Porowski Tadeusz,
Szymański Krzysztof,
Porowska Halina,
Wasilewska Anna
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13856
Subject(s) - medicine , excretion , percentile , creatinine , urinary system , phosphorus , population , physiology , pediatrics , endocrinology , statistics , materials science , mathematics , environmental health , metallurgy
Aim This study determined the specific reference values for urinary phosphorus excretion in healthy children and adolescents aged 2–18 years and evaluated whether they changed with age during growth and were gender dependent. Methods We enrolled 3913 healthy children and adolescents aged 2–18 years to this study. The study population was divided into age groups, and the analysis was performed in one‐year periods, separately for boys and girls. Urinary phosphorus excretion was analysed using four categories: P1 in mmol/24 hour units, P2 in mmol/kg/24 hours, P3 in mmol/1.73 m 2 /24 hours and P4 in mmol/mmol creatinine. Results Clear differences in urinary exertion for girls and boys were observed as well as systematic changes with age. The boys presented with significantly higher daily urinary phosphorus excretion independent of its manner of expression (p < 0.001). The median urinary phosphorus (P1) rose with age (p < 0.001). Percentile tables of phosphorous exertion are presented. Conclusion This was the largest study of urinary phosphate excretion based on a randomly selected sample of girls and boys aged 2–18 years. It highlights the importance of determining phosphorus reference values for children of different ages to provide early diagnosis and treatment for urolithiasis.