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Glomerular hyperfiltration is strongly correlated with age in Congolese children with sickle cell anaemia
Author(s) -
Aloni Michel Ntetani,
Ngiyulu René Makuala,
Ekulu Pépé Mfutu,
Mbutiwi Fiston IkwaNdol,
Makulo Jean Robert,
GiniEhungu Jean Lambert,
Nseka Nazaire Mangani,
Lepira François Bompeka
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13784
Subject(s) - medicine , microalbuminuria , glomerular hyperfiltration , renal function , body mass index , albuminuria , creatinine , urology , endocrinology , diabetic nephropathy , kidney
Aim Glomerular hyperfiltration is an early marker of sickle cell nephropathy and can lead to microalbuminuria and renal failure. Our aim was to identify the associated risk factors, as these could be of preventative importance. Methods We recruited 150 children with sickle cell anaemia (SCA), aged two to 18 years and living in Kinshasa, the Democratic Republic of Congo. Hyperfiltration and microalbuminuria were defined as an estimated glomerular filtration rate of less than 140 mL/min/1.73 m² and an albumin creatinine ratio of between 30 and 299 mg/g, respectively. Independent determinants of hyperfiltration were assessed using logistic regression analysis. Results Glomerular hyperfiltration was observed in 60 (40%) children, who were significantly older (10.2 ± 4.1 versus 7.9 ± 4.3 years, p = 0.001) and had a lower body mass index level (14.7 ± 2.3 versus 15.0 ± 2.3 kg/m 2 ) than the 60% without. A higher proportion had microalbuminuria (25.0 versus 13.3%), but the difference was not statistically significant (p>0.05). Increased age and decreased body mass index were the main independent factors associated with glomerular hyperfiltration in the multivariate analysis. A quarter (25%) of the 60 children with SCA with glomerular hyperfiltration had microalbuminuria. Conclusion Glomerular hyperfiltration was a common finding in this study and was significantly associated with age.