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Abnormal neurodevelopmental outcomes are very likely in cases of bilateral neonatal arterial ischaemic stroke
Author(s) -
Jin Ju Hyun,
Shin Jeong Eun,
Lee Soon Min,
Eun Ho Seon,
Park Min Soo,
Park Kook In,
Namgung Ran
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13655
Subject(s) - medicine , ischaemic stroke , arterial ischemic stroke , stroke (engine) , ischemic stroke , cardiology , pediatrics , ischemia , mechanical engineering , engineering
Aim Neonatal arterial ischaemic stroke ( AIS ) is an important cause of severe neurological disability. This study aimed to analyse the clinical manifestations and outcomes of AIS patients. Methods We enrolled neonates with AIS admitted to Severance Children's Hospital and Gangnam Severance Hospital between 2008 and 2015. AIS was confirmed using magnetic resonance imaging ( MRI ). We retrospectively reviewed the clinical manifestations, MRI findings, electroencephalography ( EEG ) findings and neurodevelopmental outcomes. Results The study comprised 29 neonates (18 boys). The mean follow‐up period was 15.4 months (range 6–44 months), and the mean age at diagnosis was 8.1 days. Seizure was the most common symptom (66%). Bilateral involvement was more common than unilateral involvement (52%). The middle cerebral artery was the most commonly identified territory (79%). Abnormal EEG findings were noted in 93% of the cases. Neurodevelopment was normal in 11 (38%) patients, while cerebral palsy and delayed development were noted in eight (28%) and six (21%) patients, respectively. Patients with bilateral involvement were very likely to have abnormal neurodevelopmental outcomes. Conclusion Our study showed that abnormal neurodevelopmental outcomes were very likely after cases of neonatal AIS with bilateral involvement, and clinicians should consider early and more effective interventions in such cases.