Premium
Adiposity rebound from three to six years of age was associated with a higher insulin resistance risk at eight‐and‐a‐half years in a birth cohort study
Author(s) -
Mosuwan L,
McNeil E,
Sangsupawanich P,
Chittchang U,
Choprapawon C
Publication year - 2017
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13639
Subject(s) - medicine , insulin resistance , cohort , cohort study , pediatrics , insulin , demography , sociology
Aim The association between adiposity rebound and insulin resistance in middle childhood has seldom been studied. We examined the effect of body mass index ( BMI ) velocity and early adiposity rebound on the insulin resistance of prepubertal children. Methods BMI data from a longitudinal follow‐up of a birth cohort in Thailand were used. The homoeostatic model assessment of insulin resistance ( HOMA ‐ IR ) was calculated from 12‐hour fasting plasma glucose and serum insulin at eight‐and‐a‐half years of age. BMI velocity was calculated from four periods: zero to one, one to three, three to six and six to eight‐and‐a‐half years of age. A multiple linear regression model was used to assess the association of BMI velocity during these four periods and insulin resistance at the age of eight‐and‐a‐half years. Results In 814 children – 76.7% of the initial cohort – BMI velocities between years one to three, three to six and six to eight‐and‐a‐half years were positively associated with HOMA ‐ IR levels after adjusting for demographic, behavioural and socio‐economic factors. Children who had BMI gains between three and six years had mean HOMA ‐ IR values that were 43% higher than those who did not. Conclusion BMI velocity during early and middle childhood, and early adiposity rebound between three and six years, was associated with a higher insulin resistance risk at eight‐and‐a‐half years.