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A thicker intima‐media carotid wall was found in a cohort of children with recent onset migraine
Author(s) -
Parmeggiani Lucio,
Salandin Michela,
Egger Flavio,
Lupi Fiorenzo,
Primerano Marco,
Radetti Giorgio
Publication year - 2016
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13611
Subject(s) - medicine , migraine , cohort , intima media thickness , stroke (engine) , disease , cardiology , homeostasis , population , vascular disease , cohort study , pediatrics , carotid arteries , mechanical engineering , environmental health , engineering
Aim Migraine affects approximately 10–20% of the general population, including children and adolescents, and an association between migraine and increased risks for cardiovascular disease and stroke have been reported in adult patients. This study aimed to address the lack of data on children with migraine. Methods This study comprised 30 children and adolescents (16 male) with migraine. We evaluated their biochemical profile, glucose homeostasis, vascular function by flow‐mediated dilatation and arterial structure by carotid intima‐media thickness ( cIMT ). A group of 32 age, sex and auxologically matched children (17 male) served as controls. Results The group of children with migraine had a normal biochemical profile and glucose homeostasis, but presented with significantly thicker cIMT than the control group (0.48 ± 0.07 mm versus 0.45 ± 0.04, p < 0.05). Conclusion We observed a significantly thicker cIMT in children with migraine compared with the controls. The brief time interval between the onset of the disease and the time of the study makes it unlikely that repetitive migraine attacks could be responsible for the thickening of the cIMT . Thus, it may be speculated that primitive vascular function abnormalities were wholly or partly responsible for the development of migraine in this paediatric cohort.