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Chorioamnionitis at birth does not increase the risk of neurodevelopmental disability in premature infants with bronchopulmonary dysplasia
Author(s) -
Bashir Rani A.,
Bhandari Vineet,
Vayalthrikkovil Sakeer,
Rabi Yacov,
Soraisham Amuchou,
Tang Selphee,
Al Awad Essa,
Lodha Abhay
Publication year - 2016
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13556
Subject(s) - medicine , bronchopulmonary dysplasia , chorioamnionitis , pediatrics , gestational age , odds ratio , cerebral palsy , obstetrics , pregnancy , physical therapy , genetics , biology
Aim To compare preterm infants with no bronchopulmonary dysplasia ( BPD ), BPD with chorioamnionitis ( BPDC ) and BPD with no chorioamnionitis ( BPDNC ) for the association with neurodevelopmental disability ( NDD ) at three years corrected age. Methods Demographic and outcome data of infants with birthweight ( BW ) ≤1250 g born during two epochs (1995–2000 and 2002–2007 with an interim washout period of one year) were compared on the basis of whether they had BPD , chorioamnionitis or both. Any NDD was considered present if there was either mild–severe cerebral palsy ( CP ), cognitive delay, visual or hearing impairment. Logistic regression modelling was performed. Results Infants (n = 1009) were included into three groups – no BPD (n = 442), BPDNC (n = 437) and BPDC (n = 130). The adjusted odds ratio (aOR) of any NDD at three years in infants with BPDC versus BPDNC was 1.37; 95% CI 0.85–2.20, and for CP the aOR was 1.66; 95% CI 0.76–3.62. Infants in the BPDC group were of lower BW , gestational age and had longer length of hospital stay, duration of mechanical ventilation, more blood transfusions and sepsis compared to BPDNC and no BPD groups (all p < 0.001). Conclusion Chorioamnionitis was not associated with any increase in the odds of NDD in infants with BPD at three years corrected age.