Premium
Changes in biomarkers during a six‐month oral immunotherapy intervention for cow's milk allergy
Author(s) -
Salmivesi Susanna,
Paassilta Marita,
Huhtala Heini,
Nieminen Riina,
Moilanen Eeva,
Korppi Matti
Publication year - 2016
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13550
Subject(s) - medicine , resistin , immunoglobulin e , allergy , immunology , placebo , gastroenterology , eosinophil , adipokine , antibody , leptin , asthma , pathology , alternative medicine , obesity
Abstract Aim Oral immunotherapy ( OIT ) is a promising but still experimental method to treat children with cow's milk ( CM ) allergy ( CMA ). We evaluated changes in allergic, immunological and inflammatory parameters, which happened during the six‐month OIT for CMA . Methods We treated 28 school‐aged children with CMA using OIT with a double‐blind placebo‐controlled design. After the controlled study finished, the placebo group was treated with the same but open‐label OIT protocol. Sixteen immune variables were tested before and after the six‐month OIT . Results Before OIT , the median serum CM ‐specific immunoglobulin (Ig) E was 18.0k IU /L in the intervention group and 9.4k IU /L in the placebo group (p = 0.46). At six months, interleukin ( IL )‐6 and IL ‐10 were significantly higher in the intervention group. When the changes during the blinded and open OIT were analysed together for both groups, blood eosinophils and serum total IgE decreased and milk‐specific IgG and IgG4, serum IL ‐4 and IL ‐6, and serum leptin and resistin increased significantly. Conclusion Preliminary evidence was found that markers of allergy such as blood eosinophils and serum IgE decreased and milk‐specific IgG and IgG4 increased during OIT . Adipokines, leptin and resistin, which functionally are cytokines linked to Th1‐type response, increased during OIT .