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Haemolytic and nonhaemolytic neonatal jaundice have different risk factor profiles
Author(s) -
Lee Brian K.,
Le Ray Isabelle,
Sun Ji Yu,
Wikman Agneta,
Reilly Marie,
Johansson Stefan
Publication year - 2016
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13470
Subject(s) - jaundice , medicine , pregnancy , pediatrics , obstetrics , population , risk factor , small for gestational age , birth weight , gestational age , cohort , odds ratio , environmental health , genetics , biology
Aim This study examined maternal and pregnancy risk factors for haemolytic and nonhaemolytic neonatal jaundice in a large population‐based cohort study. Methods We conducted a cohort study of 1 019 220 singleton live births from the Swedish medical birth register from 1987 to 2002, using information on neonatal jaundice and maternal and pregnancy characteristics. Diagnoses of gestational hypertensive disorders were obtained by linkage to the national inpatient register. Multivariate logistic regression analysis provided odds ratios for the risk factors of both forms of jaundice. Results A total of 6057 (0.6%) births were affected by haemolytic jaundice and 36 869 (3.6%) by nonhaemolytic jaundice. The strongest risk factors for haemolytic jaundice were maternal alloimmunisation, blood group O and neonatal jaundice in older siblings. For nonhaemolytic jaundice, the strongest risk factors were preterm birth, neonatal jaundice in older siblings, maternal origin from East or South‐East Asia and maternal obesity. We estimated that 13% of haemolytic jaundice was attributable to alloimmunisation and 39% of nonhaemolytic jaundice was attributable to preterm birth. Conclusion Haemolytic and nonhaemolytic neonatal jaundice had different risk factor profiles. Interventions to reduce maternal alloimmunisation, preterm birth and maternal obesity may lower the prevalence of neonatal jaundice and the risk of consequent neurological complications.