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Kawasaki disease and cardiovascular risk: a comprehensive review of subclinical vascular changes in the longer term
Author(s) -
Chen Katherine Y. H.,
Curtis Nigel,
Dahdah Nagib,
Kowalski Remi,
Cheung Michael,
Burgner David P.
Publication year - 2016
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13367
Subject(s) - medicine , subclinical infection , kawasaki disease , disease , cardiology , vascular disease , endothelial dysfunction , prospective cohort study , carotid arteries , artery
Studies of subclinical vascular changes post‐Kawasaki disease indicate that, in general, individuals with a history of coronary artery aneurysms have increased carotid intima–media thickness, evidence of endothelial dysfunction, and increased arterial stiffness, possibly indicative of heightened cardiovascular risk. The results are less consistent for low‐risk groups. Conclusion Until data are available from larger prospective studies, it is prudent to advise families of individuals with a history of Kawasaki disease to minimise traditional modifiable cardiovascular risk factors.