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Antecedents of inflammation biomarkers in preterm newborns on days 21 and 28
Author(s) -
Leviton Alan,
Allred Elizabeth N.,
Fichorova Rai.,
Kuban Karl C.K.,
O'Shea T. Michael,
Dammann Olaf
Publication year - 2016
Publication title -
acta paediatrica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.772
H-Index - 115
eISSN - 1651-2227
pISSN - 0803-5253
DOI - 10.1111/apa.13286
Subject(s) - medicine , quartile , systemic inflammation , gestation , inflammation , odds ratio , gestational age , physiology , pregnancy , obstetrics , pediatrics , confidence interval , biology , genetics
Aim Most studies of systemic inflammation in very preterm newborns focus on assessments made during the first two weeks. The purpose of this study was to identify some of the antecedents of systemic inflammation evident during postnatal weeks three and four. Methods We measured the protein concentrations in blood spots collected on postnatal days 21 ( N = 176) and 28 ( N = 157) from infants born before the 28th week of gestation and sought correlates of measurements in the top quartile. Odds ratios of elevated concentrations were calculated for the most obvious correlates. Results Infants born for maternal and foetal indications were more likely than their peers to have top quartile concentrations of IL ‐beta, IL ‐8, TNF ‐alpha and ICAM ‐1 on both days 21 and 28. Similarly, infants whose birthweight Z‐score was <−2 or between −1 and −2 were also more likely than their peers to have elevated concentrations of these proteins. Conclusion Markers of systemic inflammation in the very preterm newborn during the third and fourth postnatal weeks are most strongly associated with maternal and foetal indications for (very preterm) delivery and their common correlate/consequence, foetal growth restriction.