PHACE syndrome – clinical features, aetiology and management

PHACE syndrome comprises a spectrum of anomalies including p osterior fossa malformations, h aemangioma, a rterial anomalies, c ardiac defects and e ye anomalies. PHACE should be considered in any patient with a large facial segmental infantile haemangioma ( IH ), and multidisciplinary management is crucial. Low‐dose propranolol is effectively for the treatment of IH associated with PHACE syndrome. Recent evidence suggests IH is comprised of mesoderm‐derived haemogenic endothelium. Conclusion The embryonic developmental anomaly nature of IH provides an insight into the origin of PHACE syndrome.